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A trial of alogliptin (EXAMINE) was performed in 5380 patients with an acute coronary syndrome
This regulatory effect is partly mediated via the AMPK/sirtuin-1 (SIRT1) axis, as knockdown of SIRT1 abrogated the lipid-lowering and autophagy-inducing effects of GLP-1RAs, highlighting a crucial role of this pathway in regulating lipid metabolism by facilitating degradation of lipid droplets, thus preventing excessive lipid accumulation (12)
& Baeuerle, P
Sources: CLC016634.A This content is not intended to be a substitute for professional medical advice, diagnosis or treatment
As Director of the Metabolism & Body Composition Laboratory, one of Dr
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