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Cold Spring Harbor Symposia on Quantitative Biology , 72, 579597
Is Brain Fog Real
As a synthetic analog of its endogenous exendin-4, compared with exendin-4, LIXI deleted one proline and added six lysine residues, which increased its binding affinity with the GLP-1R by four times and increased its circulating half-life (58, 59)
Furthermore, dedicated cardiovascular outcome trials (LEADER, SUSTAIN-6, REWIND)[26, 28, 29] have demonstrated consistent reduction in major adverse cardiovascular events with long-acting GLP-1 RAs, particularly in people with established ASCVD
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