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Cell Host Microbe 4:35061

For the adults 60, the people who were homozygous for one of the polymorphisms (31% of the population studied) had average MMA levels of 420 nmol/l

Any cellular or metabolic stress that reduces ATP production (e.g., heat shock, hypoxia, ischemia, glucose deprivation) or accelerates ATP consumption (e.g., contraction of skeletal muscle) will increase the ADP/ATP ratio, which will be amplified by the action of adenylate kinase, resulting in increased AMP/ATP with the consequent activation of AMPK (Figure 3)

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