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Deficits in these metabolites, especially SAM are potentially important for DNA and histone methylation in the brain

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A Systematic Review of the Antidepressant Effects of Glucagon-like Peptide 1 (GLP-1) Functional Agonists: Further Link between Metabolism and Psychopathology: Special Section on "Translational and Neuroscience Studies in Affective Disorders"

This phenomenon is a genetic defense mechanism against starvation, honed over centuries of historical famine due to epidemics and wars