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Most weight loss occurs within the first 68 to 72 weeks of treatment, but some people notice appetite changes within a few weeks
However, we would suggest that future clinical trials should aim to assess the cost-effectiveness of screening older people with obesity who are undergoing weight management interventions for evidence of sarcopenia, through clinical evaluation including hand grip tests, which are accurate biomarkers for overall strength and function, bone mineral density and consequent fracture risk, and cardiometabolic disease [123]
& Vance, D
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