There are usually ways to address libido changes without discontinuing treatment, such as dose adjustments, nutritional changes, or adding hormone support
[I]f youre going to use an additional dose a week later, you may not have the same sterility as the first four doses
And because GLP-1s slow gastric emptying, people naturally drink less - sometimes far less - without noticing
Consequently, only a handful of novel PEs have progressed into commercial use over the last few decades, with sodium salcaprozate (SNAC) in the oral semaglutide tablet (Rybelsus) being one of the most clinically advanced examples ( Because of these constraints, formulation development in oral peptide delivery has largely proceeded through iterative optimization within a narrow set of established PEs, rather than broad exploration of new excipient classes (Maher and Brayden, 2021)
This is a significant convenience advantage over survodutide, which would likely require manual injection from vials initially (assuming it follows the typical path of newer injectables)