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Davies, M.J., et al., CagrilintideSemaglutide in Adults with Overweight or Obesity and Type 2 Diabetes
Deficiency in B12 can lead to demyelination, resulting in neurological symptoms such as numbness, tingling, impaired coordination, and cognitive decline
In states of negative energy balance (fasting, BW/FM loss, caloric restriction, hypoglycemia), AgRP neurons are activated leading to increased hunger, increased food seeking and ingestion, and decreased input from eating-inhibitory mechanisms
Vitamin B12, also known as cobalamin , plays a crucial role in various metabolic processes within the body, including the formation of red blood cells, neurological function, and energy production
In the STEP 1 semaglutide trial (Wilding et al., NEJM , 2021) and the SURMOUNT-1 tirzepatide trial (Jastreboff et al., NEJM , 2022), nausea affected roughly 44% of semaglutide patients and about 24% of tirzepatide patients at the maximum dose
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