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The acylation modification gives retatrutide a half-life of approximately six days, allowing once-weekly dosing, but that long half-life also means dosing errors compound over time rather than resolving quickly
The peptide shares a 97% homology with the structure of the active form of the GLP-1 hormone, which allows liraglutide to bind and activate the GLP-1 receptors in the pancreas, brain, and other organs [4]
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