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The 6.5 percentage point difference between medications may sound modest on paper, but for someone weighing 250 pounds it is the difference between losing 34 pounds or 50 pounds

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The relationship between dose, route of administration, and clinical outcomes requires systematic investigation to establish therapeutic ranges and maximize efficacy while minimizing potential risks

Some insurance plans require the patient to try losing weight through a physician-supervised weight loss program before they will cover Contrave. The Aetna plans that list Contrave as a non-preferred brand also typically require prior authorization

Results vary from person to person, but many patients start seeing noticeable changes within 4-6 weeks of beginning treatment