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Gastrointestinal adverse events were predominantly limited to initial dosing, while dose escalation resulted in lower discontinuation rates owing to these adverse events than among patients who remained on the starting dose
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The ascorbic acid inhibits adipocyte differentiation by inhibiting adenylate cyclase, acting as a global regulator of intracellular cyclic adenosine monophosphate (cAMP) levels and sodium-dependent vitamin C transporter 2 (SVCT2), and is probably involved in these differentiation processes [28] with suppression of peroxisome proliferator-activated receptor and reduce visceral obesity [29]
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10.1080/15548627.2020.1822097 160 SunW.LiuX.ZhangH.SongY.LiT.LiuX.et al (2017)
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