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Compounded medications may differ in potency, purity, risk, and side-effect profile from commercially available products

12-14 In phase III clinical studies in which exenatide was administered concomitantly with metformin, an SU, or metformin plus an SU, 48% of the 483 patients receiving exenatide 10 mcg twice daily reported nausea compared to 18% of the 483 patients receiving placebo

Unlike native amylin, which is rapidly degraded, Cagrilintides structural modifications allow for once-weekly subcutaneous administration, improving clinical practicality and adherence