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In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]
This damage leads to a condition known as endothelial dysfunction, characterized by the breakdown of the endothelial glycocalyx and a severe reduction in the bioavailability of nitric oxide (NO), a molecule essential for healthy blood flow and vascular dilation
initially generated alarming headlines
general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively
