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However, clinical research increasingly recognized that patients with metabolic diseases frequently experience clusters of systemic complications, including heart failure (HF), chronic kidney disease (CKD), and fatty liver disease, that single-target drugs historically failed to address comprehensively
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The compounds are genuinely effective at producing weight loss, but sustainable success requires addressing the whole person
For antihypertensive drugs like ACE inhibitors (lisinopril, ramipril), only minor changes in drug levels have been noted, which are generally not clinically significant
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