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ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis

If it is broken down, it may not function as the "master antioxidant" you intended it to be

After injection, it covalently bonds to Cys34 of circulating serum albumin eliminating DPP-IV cleavage and extending half-life from 7 minutes to 5.88.1 days

N-Acetyl-L-Cysteine functions as a precursor to glutathione, one of the most important antioxidant molecules produced in the body