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2.1% (consistent with weight loss rate) No Safety Signals: No increased risk of pancreatitis, thyroid tumors, or major CV events Historic Achievement: REDEFINE-1 demonstrated that CagriSema produces the highest mean weight loss (22.7%) ever reported for an obesity pharmacotherapy in a Phase 3 trial
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Thus, the JMF4073 sensitivity is inversely correlated with ATF4 and GSH levels
This limitation could be addressed with a simultaneous MRS-fMRI acquisition (e.g., Craven et al., 2024)
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