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Razuk V, Chiarito M, Cao D, Nicolas J, Pivato CA, Camaj A et al (2022) SGLT-2 inhibitors and cardiovascular outcomes in patients with and without a history of heart failure: a systematic review and meta-analysis

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It's actually working exactly as designed, but it's responding to the wrong signal

Andrew Huberman: Yeah, that's very helpful

Gln depletion therapy can inhibit Gln metabolism in tumor cells, but in colon cancer, it has been observed that Gln depletion promotes the expression of the aspartate/glutamate transporter SLC1A3 in tumor cells, increasing the intracellular glutamate concentration and promotes Gln synthesis