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This distinction is important because it allows GLP-1 receptor agonists to be discussed as a potential component of obesity-directed KOA care while avoiding the stronger, currently unproven claim that they directly modify joint structure or intra-articular disease activity in humans (Ryan et al., 2025)

10.4103/1673-5374.332127 382 RogersG

Research shows that when people stop using the medication, they can regain up to two-thirds of lost weight within a year

However, some experience persistent dry mouth throughout treatment, especially at higher doses

While some studies reported that the peripheral BDNF levels in AD patients were decreased [138, 142,143,144], others found no difference or even enhanced BDNF concentrations in AD patients [145,146,147]