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5 7 Neither has an adequately powered randomized human trial for the systemic musculoskeletal uses advertised

The access to the primary care and linked datasets requires approval but can be requested via applications to the Clinical Practice Research Datalink Research Data ( Statistical codes are available at: ( Abbreviations SGLT2: Sodium-glucose cotransporter 2 GLP1: Glucagon-like peptide-1 DPP4: Dipeptidyl peptidase-4 CARMELINA: The CArdiovascular and Renal Microvascular outcomE study with LINAgliptin CAROLINA: CARdiovascular Outcome study of LINAgliptin versus glimepiride in patients with type 2 diabetes BMI: Body mass index eGFR: Estimated glomerular filtration rate HbA1c: Hemoglobin A1c VD: Vascular dementia AD: Alzheimers disease HR: Hazard ratio IRD: Incidence rate difference CI: Confidence interval PPV: Positive predictive value CPRD: Clinical Practice Research Datalink ONS: Office for National Statistics HES APC: Hospital Episode Statistics Admitted Patient Care OPCS: The UK Office of Population, Census and Surveys classification ICD-10: International Statistical Classification of Diseases version 10 References Gudala K, Bansal D, Schifano F, Bhansali A

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Potential muscle-related effects include: Improved body composition Reduced visceral fat Mild increases in lean mass In a randomized, placebo-controlled study in HIV-infected adults with abdominal fat accumulation, daily subcutaneous tesamorelin for six months significantly reduced visceral adipose tissue compared with placebo and also increased trunk and total lean body mass, indicating improved overall body composition beyond just weight changes