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Hypoglycemic Drugs Insulin Secretagogues Sulfonylureas 1st Generation Sulfonylureas: Tolbutamide & Chlorpropamide RARELY PRESCRIBED (lower potency, greater toxicity) Trade Names: Tolbutamide (Orinase , Oramide ) Chlorpropamide (Diabinese ) Drug Class: oral hypoglycemic, sulfonylurea, first generation The use of 1st generation drugs has been replaced by newer generation sulfonylureas (mentioned here for historical purpose only) Keywords 2nd Generation Sulfonylureas: Glimepiride, Glipizide & Glyburide Fewer drug interactions, & side effects, more commonly prescribed Drugs & Trade Names: Glimepiride (Amaryl ) Glipizide (Glucotrol , Glucotrol XL ) Glyburide (DiaBeta , Micronase ) Drug Class: oral hypoglycemic, sulfonylurea, second generation Mechanism of Action: blocks ATP-regulated K channels causing depolarization that results in Ca influx and enhanced insulin release from pancreatic -cells (see Figure 1 in Beta Cell Pharmacology)

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