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Palmero S, Bottazzi C, Costa M, Leone M, Fugassa E
It is uncommon for most people to be B12 deficient, but the elderly, vegetarians and those infected with HIV are most at risk
First, implementing the protocol in 40 countries and 50 languages has logistical challenges and assumes that the outcome measure variability and effect sizes are similar enough to stay within the assumptions of the sample size modeling
The SURMOUNT Phase 3 clinical trial programme demonstrated average weight reductions of 20-22% over 72 weeks at the highest doses
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