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By promoting the conversion of acetyl-CoA to acetylcarnitine, carnitine reduces the ratio of acetyl-CoA/CoA, thereby reducing the activity of PDH kinase and restoring the activity of PDH, allowing more pyruvate to enter the mitochondria for oxidation to produce energy [288]

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It's important to note that while these treatments are promising, they each have hurdles to overcome in terms of demonstrating efficacy, safety, and tolerability in a challenging and varied patient population like that of PWS