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Hypothalamus & Pituitary: GLP-1 enhances GnRH release via kisspeptin/GABA neurons, leading to increased LH and FSH secretion

If cost is a barrier, a lower or less frequent dose may be a reasonable, pragmatic approach, recognizing that this needs to be individualized with close monitoring

Consistent reconstitution techniques help ensure that each weekly dose delivers the intended results in ongoing research

Monitoring the blood pressure is recommended

A modest increase in resting heart rate was also observed in some participants receiving higher doses, which is an anticipated effect of glucagon receptor agonism and warrants ongoing monitoring in future trials