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Vitamin B12 absorption occurs primarily in the terminal ileum through intrinsic factor-mediated absorption (for both dietary and supplemental B12) and passive diffusion (particularly relevant for high-dose supplements)
Reported effects are generally mild and may include injection-site reactions (redness, soreness, swelling), nausea, stomach upset, headache, or fatigue
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The copper(II) complex modulates extracellular matrix remodeling through stimulation of collagen synthesis, glycosaminoglycan production, and growth factor signaling
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