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improved gut permeability may reduce the passage of inflammatory compounds into circulation
The future of weight management lies not in single-agent approaches, but in thoughtfully constructed combination strategies that address the multifaceted nature of metabolic disease
Some carry more serious consequences when depleted
This did not present a risk in the researchers sample because they excluded people with body-mass indices (BMIs) lower than 23 (the World Health Organization considers BMIs 18.5 24.9 normal), and most study participants had a BMI of 30 or more (classified as obese)
To further test the extent of this and specifically whether metformin's activity extended to the brain the researchers used a mouse model, breeding mice that had been genetically modified to lack the protein Rap1 in a part of the brain called the ventromedial nucleus of the hypothalamus (VMH)
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