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Recent research identified a cystatin, CsCPI1, a cysteine proteinase inhibitor from the tea plant Camellia sinensis (L.)
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This is consistent with the outcomes of previous studies in people with type 2 diabetes, in which metformin, even after sustained exposure, did not affect insulin sensitivity, as assessed using hyperinsulinaemiceuglycaemic clamp techniques [39, 40]
Researchers compare dose-dependent responses to establish concentration-effect relationships in these in vitro systems
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