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Pfizer (PFE) announced early Monday that it is halting a late-stage trial of its GLP-1 pill candidate, danuglipron, dashing hopes of the company entering the obesity space in the near term
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To tighten barrier integrity and induce BBB properties, a cocktail of small molecules, cARLA, was applied to activate the cyclic AMP and Wnt/-catenin and inhibit the TGF- signaling pathways (Fig
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