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First, the biodistribution of the liposomal formulation was not directly assessed, limiting the ability to correlate regional biochemical effects with drug delivery efficiency

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10,33 With regard to the secondary outcome of HF hospitalisation, the results were neutral, with LEADER showing a non-significant relative risk reduction (RRR) of 13% with liraglutide compared with placebo and SUSTAIN-6 showing no significant difference between the semaglutide and placebo treatment groups

Engagement is happening, but resolution-style replies are rare