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Similarly, gypenosides, bioactive saponins from Gynostemma pentaphyllum , exhibit potent lipid-lowering activity and modulate gut microbiota composition in high-fat diet-fed rats, suggesting potential gutkidney axis-mediated metabolic benefits in DKD (216)

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Phase 2 and Phase 3 trials are expected to report results over the next two to four years, and regulatory discussions about potential addiction indications are already beginning