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While this slowing often attenuates over time with continued treatment, the effect may persist with long-acting agents and varies between individuals

I mean, sometimes their body, these kids cannot detoxify themselves and they're full of toxins

A possible explanation is that DPP-IV inhibition could not raise the GLP-1 levels sufficiently to therapeutic range when the basal GLP-1 level was too low to begin with (33)

It exhibits remarkable physicochemical properties, including resistance to enzymatic degradation and acidic environments, which are often limiting factors for peptide-based compounds (Jzwiak et al