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Published online ahead of print September 23, 2017
Figure 2 shows the cumulative incidence curves for major adverse cardiovascular events, with a lower cumulative incidence for the GLP-1 receptor agonist-SGLT-2 inhibitor combination and the curves diverging after eight months of use
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It was initially postulated to be a compensatory mechanism to the blood pressure lowering effect of GLP-1 RAs that was possibly mediated by their vasodilatory effect [9, 31] and/or increased urinary sodium excretion [32]
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