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The risk of bias was graded as low, unclear or high via a systematic assessment on five domains: randomization process, deviations from intended interventions, missing outcome data, measurement of the outcome and selection of the reported result

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However, due to the complexity of the composition of the microbiome and its effect on the organism, future research needs to gain a deeper understanding of the esophageal and intestinal microbiome and their metabolites in GERD through basic research to understand how the microbiome and their metabolites influence the occurrence of GERD, and also in the pathogenesis of GERD, abnormalities in digestive tract dynamics are gradually being emphasized by researchers

Exercise: Regular physical activity, including both aerobic and strength training exercises, boosts overall fitness and weight reduction