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Parts of the Cannabis sativa plant have been controlled federally in the U.S

Some people do combine them, and there is no known dangerous interaction

It plays a role in supporting bone density by placing mechanical load on bone through contraction

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[1] [4] Published phase 2 trial data (Jastreboff et al., NEJM , 2023) reported dose ranges from 1 mg up to 12 mg weekly, with higher doses associated with greater weight loss but also increased rates of gastrointestinal side effects