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The MR analysis was primarily based on the IVW random effects model, and we used the MR-Egger model to detect and adjust for potential horizontal pleiotropy while using Cochran's Q test to assess heterogeneity among instrumental variables

for example, salinomycin can drive ferroptosis-based cell death in breast CSCs (Zhao et al., 2019), and ironmycin, a derivative of salinomycin, can specifically trigger iron accumulation in lysosomes, activating cell death pathways consistent with ferroptosis (Mai et al., 2017)

CrossRef Astaxanthin alleviates altered hepatic lipid metabolism and oxidative stress in animals fed a high-sucrose diet Matias Rodrigo Vargas, Mara del Rosario Ferreira, Paola Ins Ingaramo, Pablo Collins, Mara Eugenia DAlessandro Frontiers in Nutrition .2026;[Epub] CrossRef Metabolic Dysfunction-Associated Steatotic Liver Disease in Africa Mohamed El-Kassas, C

Furthermore, in the EMPA-REG OUTCOME trial, empagliflozin reduced the risk of both pump failure and sudden deaths ( In addition, in the EMPEROR-reduced trial, enrolling about 3700 patients affected by heart failure with reduced ejection fraction (HFrEF), empagliflozin significantly reduced the risk of heart failure hospitalization and decreased total hospitalization for HF regardless of the presence of diabetes or baseline levels of glycohemoglobin (HbA1c) ( Since the SGLT2-i benefits on HF could not be explained by anti-hyperglycemic action in any of these trials, multiple hypotheses have been raised about the potential mechanisms underlying their cardiovascular favorable effects

MB: Writing review & editing, Writing original draft, Validation, Funding acquisition