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362 Several other drugs, such as metformin, orlistat (Xenical, Alli [OTC]), and sodium-glucose co-transport 2 (SGLT2) inhibitors, also have some potential to support weight loss efforts as adjuncts to diet and exercise

These modifications are discussed in research literature for their effect on reducing binding affinity to insulin-like growth factor binding proteins, resulting in extended biological half-life in experimental models

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The key beneficial features of GLP-1 RAs are weight loss and a relatively low risk of hypoglycemia compared with other antidiabetic agents [7]

Among the seven included studies, four were at low risk [33,34,35,36], and three had a moderate risk [23, 25, 37]