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The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default

however, cases of hypercobalaminemia in leukemia, autoimmune diseases, and pulmonary and renal dysfunction have also been observed (Andrs et al., 2013

enlarged anterior or posterior fontanelles of the ventricles of the brain and flat, bowed or large ribs at skeletal examination

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