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In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)

Like with any medication or supplement, it may take time for your system to adapt to the influx of B12

Every plan includes the vial, injection supplies, provider consultation, ongoing care, and shipping

That low bioavailability alters anticipated dosing, risk, and benefit