Most of the research in these areas comes from in vitro or animal studies, and there are no high-quality clinical trials consistently showing cosmetic or lifespan-extending effects in people.33 34 66 A few small studies suggest topical ALA may offer modest benefits for skin appearance, but these findings are early and so far dont apply to oral supplementation.35 Youre using ALA for weight loss You take certain medications ALA can interact with several medications.39 These include drugs for diabetes (like insulin or metformin), thyroid medications (like levothyroxine), and certain chemotherapy agents such as alkylating agents and antitumor antibiotics
Shakibaei, F., Radmanesh, M., Salari, E., & Mahaki, B
5 Journal of Endocrinology & Metabolism (2013)Safety & tolerability of AOD-9604 in humans (no IGF-1 increase
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This review study highlights the association between reduced NAD+ and age-related diseases, including how boosting levels may improve mitochondrial health and support cognitive function
