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That doesn't necessarily mean the first medication "failed." People respond differently to GLP-1 drugs, and some tolerate or respond to one medication better than another
Cold Spring Harb Perspect Biol 4(11):a007906
This applies to medicines received through clinical trials as well as licensed products
Analgesic and antineuropathic drugs acting through central cholinergic mechanisms
The cycle runs continuously, many times a day, in every tissue with an active pool
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