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As an example, silica nanoparticles conjugated with dopamine selectively deliver antioxidants to dopaminergic neurons in vitro (89)
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For other 5-HT 4 agonists, including clebopride, cinitapride and mosapride, there is relatively weak evidence to support efficacy [73], and cisapride, which appeared to be effective at relieving symptoms, was withdrawn from the market in 2000 due to concerns about cardiovascular safety [73]
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