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Semaglutide at the highest maintenance dose (2.4 mg weekly) achieved approximately 15% body weight reduction in STEP clinical trials, compared to about 10% at lower doses

A Spearman correlation analysis confirmed that the pathological index of steatosis was negatively correlated with the hepatic GLP-1R expression level (Fig

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Adiponectin also decreases hepatic de novo glucose production and reduces free fatty acid levels in the liver (196), thereby mitigating hepatic steatosis, enhancing insulin sensitivity, and improving the circulating lipid profile ( Figure 1 Section E)

It is thought that around 25% to 33% of the total body weight lost is from lean muscle mass