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They also work in different ways
The consequences of Nrf2 impairment in CF include weakened intrinsic antioxidant defense capacity and increased intracellular H 2 O 2 levels, which contribute to the overproduction of pro-inflammatory cytokines like IL-6 and IL-8, directly linking defective antioxidant response to CFs characteristic chronic inflammation (Chen et al., 2008)
This is particularly relevant in chronic tendinopathy, where the local repair response has stalled
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