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The three year absolute risk was 2.4% (95% CI 2.1% to 2.7%) lower for SGLT-2 inhibitors than DPP-4 inhibitors (4.6% v 7.0%), 1.8% (1.4% to 2.1%) lower for GLP-1 receptor agonists than DPP-4 inhibitors (5.7% v 7.5%), and 1.2% (0.9% to 1.5%) lower for SGLT-2 inhibitors than GLP-1 receptor agonists (4.7% v 6.0%)

Food and other medications may affect absorption

[20] [21] Dehydration represents another plausible mechanism, especially in patients experiencing gastrointestinal side effects

Orforglipron is a once-daily oral pill that, unlike oral Wegovy, can be taken anytime without food or water restrictions

Lilly said most cases involving paresthesia were mild and rarely led to treatment discontinuation