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Scientists studying gastric cytoprotection identified a protein fragment with notable biological activity and subsequently isolated the pentadecapeptide now known as BPC-157

Intriguingly, the residues of c-MET II-SEMA that are involved in the binding to HGF I-K1 largely overlap with those at the c-MET I-SEMA/HGF I-K3 interface, suggesting that c-MET-SEMA cannot simultaneously bind to HGF-K1 and K3

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doi: 10.1177/1759091420962681 47 TodorichBPasquiniJMGarciaCIPaezPMConnorJR

Oxysophocarpine retards the growth and metastasis of oral squamous cell carcinoma by targeting the Nrf2/HO-1 axis