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Nonostante tali evidenze, i meccanismi attraverso cui i GLP-1RA conferiscono nefroprotezione non sono stati del tutto compresi e il loro utilizzo nella pratica clinica ancora limitato

13 Two meta-analyses of other GLP-1 RA CVOTs found that GLP-1 RAs were associated with greater rates of DR progression, but both studies found that the effect was driven by the extent of hemoglobin A1c reduction, rather than the medications themselves

IV therapy may enhance this process by improving antioxidant levels

Initially, the patient is recommended one shot daily for a week