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The vitamin is a cofactor for methionine synthase, which catalyzes the conversion of homocysteine to methioninerequired for the formation of S-adenosylmethionine, a universal methyl donor for almost 100 substrates, including DNA, RNA, hormones, proteins, and lipids

Overexpression of COX2 is reported in many types of cancer, including cutaneous melanoma, which contributes to tumor progression and angiogenesis (225)

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However, there are several issues with these values: Nutritional requirements are influenced by personal genetics [4]

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