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Differential expression (DE) analysis was performed using the limma (v3.44.3) package (Ritchie et al, 2015) with the limma-trend pipeline (Law et al, 2014) and robust empirical Bayes estimation of variances (Phipson et al, 2016)

Operating too early could mean that additional contour changes occur afterward, potentially compromising symmetry or creating the need for revision

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