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These analogues were primarily created by substituting amino acids within the peptide structure for amino acids more resistant to enzymatic cleavage
Patients who haven't responded well to other GLP-1 medications, or who have a significant amount of weight to lose and want the strongest average efficacy available, are often good candidates for tirzepatide
In the literature this combination is described in models of sarcopenia (loss of muscle mass in seniors) and post-training recovery
doi:10.1159/000355751
November 2022
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