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Skeletal Muscle Carnitine Loading Increases Fat Oxidation. Journal of Physiology

Some people notice improved hydration, energy, or mental clarity the same day, while others feel benefits gradually over the next few days

To date, tirzepatide has demonstrated CV safety when compared with pooled comparators in a meta-analysis of phase 2 and phase 3 studies with the hazard ratio of 0.80 (95% CI: 0.571.11) for MACE-4 [24]

Accurate dosing is therefore not just a safety concern

Phase 3 trials with larger populations and longer follow-up periods will be essential to characterise the safety profile more comprehensively