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Overall, the study demonstrated that high-grade serous carcinoma (HGSC) ovarian cancers can be clearly divided into groups according to GPx3 expression levels, and that GPx3 is essential for the survival of HGSC ovarian cancer cells in the unique ascitic tumor microenvironment and protect cells from extracellular oxidative stress factors (36)
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5,34 The age-standardized incidence and mortality rates were approximately 3-fold higher in males than in females, and nearly double in rural regions compared with urban areas
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