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The downstream mechanisms by which GSTP1 promotes PNT also require further investigation
To put that in perspective, the approved GLP-1 drugs achieved less weight loss in longer timeframes: for example, semaglutide (Wegovy) averages about 15% weight loss over ~16 months, and tirzepatide (Zepbound) achieved around 22.5% at 72 weeks in trials
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Gut Microbiome: Though influences immune homeostasis and thyroid hormone metabolism, recent studies show no significant microbiome difference in euthyroid individuals with or without thyroid antibodies
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